Publications

Below you will find a selection of publications from the lab. For publications that are behind a paywall, you can click on the provided link to obtain the freely available accepted manuscript version.

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment cover image

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

Van Hove H, Martens L, Scheyltjens I, De Vlaminck K, Pombo Antunes AR, De Prijck S, Vandamme N, De Schepper S, Van Isterdael G, Scott CL, Aerts J, Berx G, Boeckxstaens GE, Vandenbroucke RE, Vereecke L, Moechars D, Guilliams M, Van Ginderachter JA, Saeys Y, Movahedi K.

Nature Neuroscience, 2019, DOI: 10.1038/s41593-019-0393-4

Full Article
Identifying the variables that drive tamoxifen-independent CreERT2 recombination: Implications for microglial fate mapping and gene deletions cover image

Identifying the variables that drive tamoxifen-independent CreERT2 recombination: Implications for microglial fate mapping and gene deletions

Van Hove H, Antunes ARP, De Vlaminck K, Scheyltjens I, Van Ginderachter JA, Movahedi K.

European Journal of Immunology, 2020, DOI: 10.1002/eji.201948162

Full Article
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization cover image

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

Pombo Antunes AR, Scheyltjens I, Lodi F, Messiaen J, Antoranz A, Duerinck J, Kancheva D, Martens L, De Vlaminck K, Van Hove H, Kjølner Hansen SS, Bosisio FM, Van der Borght K, De Vleeschouwer S, Sciot R, Bouwens L, Verfaillie M, Vandamme N, Vandenbroucke RE, De Wever O, Saeys Y, Guilliams M, Gysemans C, Neyns B, De Smet F, Lambrechts D, Van Ginderachter JA, Movahedi K.

Nature Neuroscience, 2021, DOI: 10.1038/s41593-020-00789-y

Full Article
CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia cover image

CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia

Lodder C, Scheyltjens I, Stancu IC, Botella Lucena P, Gutiérrez de Ravé M, Vanherle S, Vanmierlo T, Cremers N, Vanrusselt H, Brône B, Hanseeuw B, Octave JN, Bottelbergs A, Movahedi K*, Dewachter I*.

Acta Neuropathologica Communications, 2021, DOI: 10.1186/s40478-021-01204-8

Full Article
Macrophage compartmentalization in the brain and cerebrospinal fluid system cover image

Macrophage compartmentalization in the brain and cerebrospinal fluid system

Munro DAD, Movahedi K, Priller J.

Science Immunology, 2022, DOI: 10.1126/sciimmunol.abk0391

Full Article
Single-cell RNA and protein profiling of immune cells from the mouse brain and its border tissues cover image

Single-cell RNA and protein profiling of immune cells from the mouse brain and its border tissues

Scheyltjens I, Van Hove H, De Vlaminck K, Kancheva D, Bastos J, Vara-Pérez M, Pombo Antunes AR, Martens L, Scott CL, Van Ginderachter JA, Saeys Y, Guilliams M, Vandamme N, Movahedi K.

Nature Protocols, 2022, DOI: 10.1038/s41596-022-00716-4

Full Article
Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation cover image

Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation

De Vlaminck K, Van Hove H, Kancheva D, Scheyltjens I, Pombo Antunes AR, Bastos J, Vara-Perez M, Ali L, Mampay M, Deneyer L, Miranda JF, Cai R, Bouwens L, De Bundel D, Caljon G, Stijlemans B, Massie A, Van Ginderachter JA, Vandenbroucke RE, Movahedi K.

Immunity, 2022, DOI: 10.1016/j.immuni.2022.09.005

Full Article
Immune stimulation recruits a subset of pro-regenerative macrophages to the retina that promotes axonal regrowth of injured neurons cover image

Immune stimulation recruits a subset of pro-regenerative macrophages to the retina that promotes axonal regrowth of injured neurons

Andries L, Kancheva D, Masin L, Scheyltjens I, Van Hove H, De Vlaminck K, Bergmans S, Claes M, De Groef L, Moons L*, Movahedi K*.

Acta Neuropathologica Communications, 2023, DOI: 10.1186/s40478-023-01580-3

Full Article
Infection history imprints prolonged changes to the epigenome, transcriptome and function of Kupffer cells cover image

Infection history imprints prolonged changes to the epigenome, transcriptome and function of Kupffer cells

Musrati MA, Stijlemans B, Azouz A, Kancheva D, Mesbahi S, Hadadi E, Lebegge E, Ali L, De Vlaminck K, Scheyltjens I, Vandamme N, Zivalj M, Assaf N, Elkrim Y, Ahmidi I, Huart C, Lamkanfi M, Guilliams M, De Baetselier P, Goriely S, Movahedi K*, Van Ginderachter JA*.

Journal of Hepatology, 2024, DOI: 10.1016/j.jhep.2024.07.007

Full Article
Monocytes can efficiently replace all brain macrophages and fetal liver monocytes can generate bona fide SALL1+ microglia cover image

Monocytes can efficiently replace all brain macrophages and fetal liver monocytes can generate bona fide SALL1+ microglia

Bastos J, O’Brien C, Vara-Pérez M, Mampay M, van Olst L, Barry-Carroll L, Kancheva D, Leduc S, Lievens AL, Ali L, Vlasov V, Meysman L, Shakeri H, Roelandt R, Van Hove H, De Vlaminck K, Scheyltjens I, Yaqoob F, Lombroso SI, Breugelmans M, Faron G, Gomez-Nicola D, Gate D, Bennett FC, Movahedi K.

Immunity, 2025, DOI: 10.1016/j.immuni.2025.04.006

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